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Index > Protein center > Enpp1(Gene name) > Rat
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  • Enpp1 (Gene name),
  • Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Protein name ),  ENPP1_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Enpp1(Npps;Pc1;Pdnp1);
    Protein name:
    Ectonucleotide pyrophosphatase/phosphodiesterase family member 1(E-NPP 1);
    Alternative:
    Plasma-cell membrane glycoprotein PC-1;Phosphodiesterase I/nucleotide pyrophosphatase 1;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked.
    Function:
    Involved primarily in ATP hydrolysis at the plasma membrane. Plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. In vitro, has a broad specificity, hydrolyzing other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity.
    Subcellular Location:
    Membrane Single-pass type II membrane protein Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts. In bile duct cells and cancer cells, located to the apical cytoplasmic side.
    Protein Attributes:
    Sequence length:
    906
    Sequence:
    50:
    MERDGEQAGQ | GPRHGPAGNG | RELESPAAAS | LLAPMDLGEE | PLEKAERART | 
    100:
    AKDPNTYKVL | SLVLSVCVLT | TILGCIFGLK | PSCAKEVKSC | KGRCFERTFS | 
    150:
    NCRCDAACVS | LGNCCLDFQE | TCVEPTHIWT | CNKFRCGEKR | LSRFVCSCAD | 
    200:
    DCKAHNDCCI | NYSSVCQEKK | SWVEEACETI | DAPQCPAEFE | SPPTLLFSLD | 
    250:
    GFRAEYLHTW | GGLLPVISKL | KNCGTYTKNM | RPVYPTKTFP | NHYSIVTGLY | 
    300:
    PESHGIIDNK | MYDPKMNASF | SLKSKEKFNP | LWYKGQPIWV | TANHQEVRSG | 
    350:
    TYFWPGSDVE | IDGILPDIYK | VYNGSVPFEE | RILAVLEWLQ | LPSYERPHFY | 
    400:
    TLYLEEPDSS | GHSHGPVSSE | VIKALQKVDH | IVGMLMDGLK | DLGLDKCLNL | 
    450:
    ILISDHGMEQ | GSCKKYVYLN | KYLGDVNNVK | VVYGPAARLR | PTEVPETYYS | 
    500:
    FNYEALAKNL | SCRETNQHFR | PYLKHFLPKR | LHFAKNDRIE | PLTFYLDPQW | 
    550:
    QLALNPSERK | YCGSGFHGSD | NLFSNMQALF | IGYGPAFKHG | AEVDSFENIE | 
    600:
    VYNLMCDLLG | LIPAPNNESH | GSLNHLLKKP | IYTPSHPKEE | SFLSQCPIKS | 
    650:
    VSSDLGCTCD | PSIVPIMDFE | KQFNLTTDAV | EDVYSMTVPN | GRPRNLQKQH | 
    700:
    RVCLLHQQQF | LTGYSLDLLM | PLWTSYTFLS | NDQFSTDDFS | NCLYQDLRIP | 
    750:
    LSPMHKCSYY | KSTSKLSYGF | LTPPRLNRVS | RQIYSEALLT | SNIVPMYQSF | 
    800:
    QVIWQYLHDT | VLRRYAQERN | GVNVVSGPVF | DFDYDGRYDS | SEILKQNTRV | 
    850:
    IRSQENLIPT | HFFIVLTSCK | QLSESPLKCT | ALESSAFLLP | HRPDNIESCT | 
    900:
    HGKQESAWVE | ELLALHRARV | TDVELITGLS | FYQDRQESVS | ELLRLKTHLP | 
    906:
    IFSQED
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    KEGG:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Rat E-NPP 1
    Cat.:
    E1032r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat E-NPP 1
    Cat.:
    E1032h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat E-NPP 1
    Cat.:
    E1032m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat E-NPP 1
    Cat.:
    U1032h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat E-NPP 1
    Cat.:
    U1032m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat E-NPP 1
    Cat.:
    U1032r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Rat E-NPP 1
    Cat.:
    P1032Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat E-NPP 1
    Cat.:
    P1032Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat E-NPP 1
    Cat.:
    P1032Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat E-NPP 1
    Monoclonal Antibody for Rat E-NPP 1
    Monoclonal Antibody for Rat E-NPP 1
    Protein for Rat E-NPP 1
    Protein for Rat E-NPP 1
    Protein for Rat E-NPP 1

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    Linearity
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    References
    1. 1.
      "Structural basis of allotypes of ecto-nucleotide pyrophosphatase/phosphodiesterase (plasma cell membrane glycoprotein PC-1) in the mouse and rat, and analysis of allele-specific xenogeneic antibodies."
      Banakh I. , Sali A. , Dubljevic V. , Grobben B. , Slegers H. , Goding J.W.
      Eur. J. Immunogenet.29:307-313(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);VARIANTS
      strain: Lewis.
      strain: Louvain.
      strain: Wistar.
    2. 2.
      "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
      Hoffert J.D. , Pisitkun T. , Wang G. , Shen R.-F. , Knepper M.A.
      Proc. Natl. Acad. Sci. U.S.A.103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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