Gene name:
Enpp1 (Npps;Pc1;Pdnp1) ;
Protein name:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) ;
Alternative:
Plasma-cell membrane glycoprotein PC-1 ;Phosphodiesterase I/nucleotide pyrophosphatase 1 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Homodimer; disulfide-linked.
Function:
Involved primarily in ATP hydrolysis at the plasma membrane. Plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. In vitro, has a broad specificity, hydrolyzing other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity.
Subcellular Location:
Membrane
Single-pass type II membrane protein
Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts. In bile duct cells and cancer cells, located to the apical cytoplasmic side.
Protein Attributes:
50:
MERDGEQAGQ | GPRHGPAGNG | RELESPAAAS | LLAPMDLGEE | PLEKAERART |
100:
AKDPNTYKVL | SLVLSVCVLT | TILGCIFGLK | PSCAKEVKSC | KGRCFERTFS |
150:
NCRCDAACVS | LGNCCLDFQE | TCVEPTHIWT | CNKFRCGEKR | LSRFVCSCAD |
200:
DCKAHNDCCI | NYSSVCQEKK | SWVEEACETI | DAPQCPAEFE | SPPTLLFSLD |
250:
GFRAEYLHTW | GGLLPVISKL | KNCGTYTKNM | RPVYPTKTFP | NHYSIVTGLY |
300:
PESHGIIDNK | MYDPKMNASF | SLKSKEKFNP | LWYKGQPIWV | TANHQEVRSG |
350:
TYFWPGSDVE | IDGILPDIYK | VYNGSVPFEE | RILAVLEWLQ | LPSYERPHFY |
400:
TLYLEEPDSS | GHSHGPVSSE | VIKALQKVDH | IVGMLMDGLK | DLGLDKCLNL |
450:
ILISDHGMEQ | GSCKKYVYLN | KYLGDVNNVK | VVYGPAARLR | PTEVPETYYS |
500:
FNYEALAKNL | SCRETNQHFR | PYLKHFLPKR | LHFAKNDRIE | PLTFYLDPQW |
550:
QLALNPSERK | YCGSGFHGSD | NLFSNMQALF | IGYGPAFKHG | AEVDSFENIE |
600:
VYNLMCDLLG | LIPAPNNESH | GSLNHLLKKP | IYTPSHPKEE | SFLSQCPIKS |
650:
VSSDLGCTCD | PSIVPIMDFE | KQFNLTTDAV | EDVYSMTVPN | GRPRNLQKQH |
700:
RVCLLHQQQF | LTGYSLDLLM | PLWTSYTFLS | NDQFSTDDFS | NCLYQDLRIP |
750:
LSPMHKCSYY | KSTSKLSYGF | LTPPRLNRVS | RQIYSEALLT | SNIVPMYQSF |
800:
QVIWQYLHDT | VLRRYAQERN | GVNVVSGPVF | DFDYDGRYDS | SEILKQNTRV |
850:
IRSQENLIPT | HFFIVLTSCK | QLSESPLKCT | ALESSAFLLP | HRPDNIESCT |
900:
HGKQESAWVE | ELLALHRARV | TDVELITGLS | FYQDRQESVS | ELLRLKTHLP |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Rat E-NPP 1
ELISA Kit for Rat E-NPP 1
ELISA Kit for Rat E-NPP 1
Polyclonal Antibody for Rat E-NPP 1
Polyclonal Antibody for Rat E-NPP 1
Polyclonal Antibody for Rat E-NPP 1
Monoclonal Antibody for Rat E-NPP 1
Monoclonal Antibody for Rat E-NPP 1
Monoclonal Antibody for Rat E-NPP 1
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);VARIANTS
strain :
Lewis .
strain :
Louvain .
strain :
Wistar .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]